IL4 and Crohn disease: It is a member of the STAT family and plays an important role in the initiation of tumor formation and malignant transformation [50], and it has been reported that the rate of progression from ulcerative colitis to colorectal cancer, where the secretion of IL-4 and IL-13 is expressed in a large amount, is higher than that of Crohn’s disease, where Th2 cytokine secretion is relatively small [51].