CLDN2 and neoplasm: Hence, the LNL 80 group demonstrated a significant reduction in STAT6 through the inhibitory ability of IL-13, suggesting that the overexpression of claudin-2 among the causes of TJ imbalance in intestinal epithelial cells can be controlled, and furthermore, it implies the possibility of inhibiting tumor production and maintenance through IL-13/STAT6 pathway overactivation.