The progression of uveal melanoma relies on a second genetic driver event [78], such as the inactivation of BAP1 (about 60% of cases) on chromosome 3p21 [78], mutation in the Splicing Factor 3b Subunit 1 (Spliceosome Factor SF3B1) (about 25% of cases) [78], or EIF1AX mutation [78] (about 15–17% of cases [78,79]). The gene discussed is BAP1; the disease is uveal melanoma.