However, data from cohorts of patients with pSS, classified as such according to the AECG 2002 criteria, showed that this small subgroup of patients could feature a less severe phenotype than SSA-positive patients, characterized by a more marked sicca syndrome compared to anti-SSA-positive patients but more systemic manifestations than seronegative patients [25]. The gene discussed is CALR; the disease is Sjogren syndrome.