Moderate-to-severe ESSDAI, the use of immunosuppressant and/or methylprednisolone, rheumatoid factor positivity, hypergammaglobulinemia, and a lower prevalence of xerostomia are depicted by the anti-SSA-positive and atypical ANA-positive profiles, relative to the ANA-negative and non-identified ANA-positive profiles. The gene discussed is TRIM21; the disease is xerostomia.