Similarly, serum DCP, also known as protein induced by vitamin K absence or antagonist II (PIVKA-II), has been validated as a biomarker for the diagnosis of HCC over recent years [1,2,3,4,5,6,7,8,9,10,11,12,14,15,16,17,18,19,20,21,22]. The gene discussed is ACE; the disease is hepatocellular carcinoma.