Several studies have shown a correlation between serum DCP levels and the presence of microvascular invasion (MVI), and of intrahepatic metastasis, the number of tumours and poor tumour differentiation [1,2,3,4,5,7,8,9,10,12,13,14,15,16,17,18,19,20,21,23,24,25,26,27]. This evidence concerns the gene ACE and neoplasm.