CDK2 and neoplasm: On the other hand, a low cytoplasmic CDK2 expression was associated with a high tumour grade (p < 0.0001), triple-negative and HER2-enriched molecular subtypes (p = 0.01), Comedo necrosis (p = 0.002), negative ER status (p = 0.01), and negative PR status (p = 0.002) (Supplementary Table S9).