We then proceeded to nuclear/cytoplasmic CDK2 co-expression analysis, and tumours with high nuclear and high cytoplasmic CDK2 co-expression were associated with a higher tumour grade (p < 0.0001), low tubule formation (p = 0.006), higher degree of nuclear pleomorphism (p < 0.0001) and high mitosis(p < 0.0001), NST tumour type (p < 0.0001), HER2-enriched molecular subtype (p < 0.0001), presence of lympho-vascular invasion (p = 0.01), moderate and poor NPI groups (p < 0.0001), and higher Ki67 expression (p = 0.021) (Supplementary Table S4). This evidence concerns the gene ERBB2 and neoplasm.