PGR and neoplasm: In addition, a high nuclear/low cytoplasmic co-expression showed a significant association with a high tumour grade (p = 0.043), triple-negative and HER2-enriched molecular subtypes (p = 0.01), Comedo necrosis (p = 0.024), negative ER status (p = 0.004), negative PR status (p < 0.0001), and high Ki67 expression (p < 0.0001) (Supplementary Table S10).