A high nuclear CDK2/high p53 co-expression showed a significant association with a younger patient age (p = 0.03), high tumour grade (p < 0.0001), low tubule formation (p = 0.006), high degree of nuclear pleomorphism (p < 0.0001) and high mitosis (p < 0.0001), NST tumour type (p < 0.0001), HER2-enriched molecular subtype (p < 0.0001), lymph node metastasis ( p = 0.04), presence of lympho-vascular invasion (p = 0.03), poor NPI groups (p < 0.0001), and high Ki67 expression (p < 0.0001) (Supplementary Table S5). This evidence concerns the gene CDK2 and neoplasm.