The negative associations between adiponectin and the large buoyant VLDL as well as small dense LDL observed in HVs, but not in the patients with MS, are in accordance with the results of previous studies examining the relationship between adiponectin and the lipoprotein subclasses in healthy adults [23,25], as well as in obese and lean adolescents [35] and patients with T2D [38]. The gene discussed is ADIPOQ; the disease is type 2 diabetes mellitus.