DNMT1 and head and neck squamous cell carcinoma: Indeed, KiSS-1 mRNA levels have been shown to be up-regulated by HDAC and DNMT inhibitors [21,42], and KiSS-1 has been proposed to sensitize head and neck squamous cell carcinoma, lung cancer models to cisplatin, and melanoma cells to vemurafenib [38,39,40].