The subgroup analysis by cancer type further confirmed the association of high B7H4 expression with shorter OS in patients with CCA (HR = 1.84, 95% CI: 1.37–2.48), ESCC (HR = 1.64, 95% CI: 1.15–2.32), CRC (HR = 1.59, 95% CI: 1.33–1.90), and GC (HR = 1.51, 95% CI: 1.12–2.04) but not in patients with PDAC (HR = 2.29, 95% CI: 0.93–5.61), RCC (HR = 1.77, 95% CI: 0.8–3.9), and NSCLC (HR = 1.11, 95% CI: 0.50–2.49) (Figure 2D). Here, VTCN1 is linked to renal cell carcinoma.