GFAP and Cognitive impairment: In a GFAP-IL6 (glial fibrillary acidic protein-interleukin 6) transgenic mouse model, a model exhibiting neuronal loss and atrophy, chronic activation of microglia and astrocytes, increased expression of inflammatory mediators [99], and BBB disruption and age-related motor and cognitive impairment [99,100,101], apigenin decreased the number of Iba-1+ microglia in the hippocampus of GFAP-IL6 mice and altered microglial morphology, but no reversal of spatial memory impairment was observed [102].