Using human NSCLC cell lines, we have previously reported higher intact Aβ 1–40 and Aβ 1–42 levels in the media of A549 cells (p53 wild-type) than in the media of H1299 cells (p53-null), in part due to the greater proteolytic degradation of Aβ 1–40 and Aβ 1–42 in the media of H1299 cells by matrix metallopeptidase 2 (MMP2) [34]. Here, TP53 is linked to non-small cell lung carcinoma.