CEACAM5 and colorectal carcinoma: If the CEA, CA 19-9, and ucMGP values increased with disease evolution, and if the PIVKA II values decreased, an inverse U shape for PIVKA II’s evolution with respect to CRC spread would occur (430.13 ± 122.13, median value 451.75 vs. 310.05 ± 38.22, median value 316.70, p < 0.0001).