In addition, Ren et al. [45] observed that NLRP3 inflammasome in macrophages directly activated MMP-9 by cutting its own N-terminal inhibitory domain, while using a strong selective NLRP3 inflammasome inhibitor MCC950 to block inflammasome activation in macrophages could prevent the formation of an aortic aneurysm. Here, NLRP3 is linked to aortic aneurysm.