We established in a recent study that HfFucCS, a marine fucosylated chondroitin sulfate isolated from the sea cucumber species H. floridana, previously studied as an anti-SARS-CoV-2 and anticoagulant agent [46], blocks the activity of heparan 6-O-endosulfatase SULF2 and inhibits the invasion of HNSCC cancer cells into the ECM [34]. Here, SULF2 is linked to head and neck squamous cell carcinoma.