AGT and focal segmental glomerulosclerosis: To evaluate whether podocyte-specific MCP-1 production was necessary to the development of glomerular injury, specifically focal segmental glomerulosclerosis, mice were exposed to Ang II (1.5 mg/kg/day, osmotic minipump) or Adr (18 mg/kg, intravenous bolus) to induce podocyte injury (Figure 3A,G).