In AD PHF tau, the following sites are often considered to be pathologically relevant: Y18, T181, S198/S199/S202/S205, T212/S214/T217, T231/S235, S262, S396/S400/S404, S416, and S422 [112,113]; In APP/PS1 mouse synaptic sites, the early hyperphosphorylation sites appear to be 181, 198/199/202, 231, 396/400/404, and 416 [114]. The gene discussed is MAPT; the disease is Alzheimer disease.