AKT1 and cardiac hypertrophy: The activation of ROCKs may suppress the pro-survival phosphatidylinositol 3-kinase (PI3K)/Akt (protein kinase B) pathway and induce cardiac fibrosis (via the activation of profibrotic gene expression and transdifferentiation of fibroblasts into myofibroblasts) and myocardial hypertrophy in pathologic conditions [9].