In another mouse model of HF (with transverse aortic constriction), simvastatin reduced myocardial fibrosis and hypertrophy by suppressing fibroblast proliferation and myofibroblast formation through modulation of endothelial Krüppel-like factor 2 (Klf2)-TGFβ1 or KLF2-forkhead box P1 (Foxp1, endothelial transcription factor)-TGFβ1 signaling pathways [128]. The gene discussed is KLF2; the disease is hydrops fetalis.