Studies have indicated that hydroxytyrosol diminishes mitochondrial oxidative stress and neuroinflammation in Alzheimer’s disease (AD)-prone transgenic mice by triggering nuclear factor erythroid 2-related factor 2 (nrf2)-dependent gene expression [21], and EVOO polyphenols additionally boost Nrf-2 activation within the liver, resulting in the release of antioxidant enzymes [22]. This evidence concerns the gene NFE2L2 and early-onset autosomal dominant Alzheimer disease.