SGK1 was observed as intense patches at the plasma membrane and in the cytoplasm and colocalized with α-ENaC in neutrophils from patients with HTN, whereas less intense patches of SGK1 and scarce points of co-localization of SGK1 and α-ENaC were observed in neutrophils from NTI (Figure 3C). The gene discussed is SGK1; the disease is hypertensive disorder.