NEDD4L and hypertensive disorder: However, the merged images revealed co-localization of NEDD4-2 with α-ENaC in patches at the plasma membrane in neutrophils from patients with HTN, while fine aggregates of co-localization of NEDD4-2 with α-ENaC were observed at the plasma membrane and in the cytoplasm of neutrophils from NTI (Figure 3C).