MYBPC3 and hypertrophic cardiomyopathy: Bahrudin et al. [17] reported that the UPS impairment caused by the E334K mutation in cardiac myosin-binding protein C (cMyBPC) modifies the levels of channel proteins (e.g., K(v)1.5, Na(v)1.5, HCN4, Ca(v)3.2, Ca(v)1.2, SERCA, RyR2, and NCX1), leading to electrophysiological dysfunction, which may partly contribute to the observed clinical arrhythmias in hypertrophic cardiomyopathy (HCM) patients.