TNF and obesity due to melanocortin 4 receptor deficiency: The markers of inflammation related to obesity include profiles of adipose tissue-derived adipokines (namely leptin, adiponectin, and resistin), serum levels of liver-synthesized C-reactive protein (CRP), and concentrations of some inflammatory cytokines: interleukin (IL)-6, tumor necrosis factor (TNF)-α, IL-1β, produced by immune cells [110,111].