PPARG and obesity due to melanocortin 4 receptor deficiency: 14-3-3 proteins have been implicated in various medical conditions, including metabolic disorders like obesity, where 14-3-3ζ promotes adipogenesis by regulating the activity of master adipogenic factors, peroxisome proliferator-activated receptor gamma (PPAR-γ), and CCAAT/enhancer binding protein (C/EBP) α [22].