Studies have shown that inflammatory stimulation can increase the phosphorylation and proteasome degradation of IκB inhibitory protein, leading to the release of NF-κB and nuclear translocation [102], thus promoting the release of inflammatory factors, increasing the inflammatory response in the brain [103], expanding the damage to DA neurons, and thus aggravating the pathological process of PD. This evidence concerns the gene NFKB1 and Parkinson disease.