AKT1 and Parkinson disease: Microglia responding to low levels of PI3K/AKT signaling polarization leads to a neurotoxic state, whereas microglia responding to high levels of PI3K/AKT signaling polarization leads to a neuroprotective state [123], thus high expression of PI3K/AKT reduces inflammation by affecting the polarization of microglia and promoting their conversion to a neuroprotective state thereby alleviating the progression of PD.