Although a direct effect of A2AR on the viability of DA neurons was not directly tested, previous studies have reported the ability of A2AR to control the damage of neurons [85,86,87,88,89], in particular mesencephalic neurons in culture [31], as well as the loss of viability of cells used as models of DA neurons such as differentiated human neuroblastoma SH-SY5Y cells exposed to MPP+ or 6-hydroxydopamine [33,90,91]. This evidence concerns the gene ADORA2A and neuroblastoma.