In the MASLD setting, there are dysregulated miRNAs which have the potential to modulate transcription factors associated with hepatic lipogenesis and lipid or carbohydrate metabolism, such as carbohydrate response element-binding protein (ChREBP), sterol regulatory element-binding protein 1 (SREBP-1), and peroxisome proliferator-activated receptors (PPARs) [137]. The gene discussed is SREBF1; the disease is metabolic dysfunction-associated steatotic liver disease.