Between controls and PCOS-nonGH there was the expected increased BMI, insulin, HOMA-IR, CRP, testosterone, and AMH; however, the PCOS-nonGH, PCOS-GH, and PCOS-SGH did not differ for obesity between groups, thus accounting for this parameter for the serum markers measured. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.