For example, the expression of pro-inflammatory myokines IL-1β and IL-8 were both upregulated in myotubes from the T2D responders group following the aerobic exercise intervention, whereas IL-15 mRNA was increased post-intervention in the myotubes from the no-T2D and T2D non-responders groups. This evidence concerns the gene CXCL8 and type 2 diabetes mellitus.