An enhancement between BTZ and TIG in terms of the production of apoptosis was observed only in one sample from a patient with symptomatic MM after a rapid evolution from solitary plasmacytoma, with the appearance of multiple bone lesions, noteworthy elevation of beta-2 microglobulin, LDH increase, anemia, renal involvement, and fast-onset hypercalcemia. This evidence concerns the gene B2M and hypercalcemia disease.