Furthermore, our data on regulation of metastasis by GFPT1 is supported by studies showing a tight link between the HBP/GFPT1 and EMT [33,46] and a study demonstrating that the downregulation of GFPT1 inhibits cell motility and metastasis in a mouse model of CRC murine colon adenocarcinoma cells [47]. Here, GFPT1 is linked to colorectal carcinoma.