To test whether levels of GFPT1, OGT and GlcNAc are higher in human CRC as compared to normal mucosa and whether the expression of FASN, GFPT1 and OGT correlate with the level of O-linked glycosylated proteins, we assessed the expression of these enzymes and the level of O-GlcNAc in human CRC specimens. This evidence concerns the gene OGT and colorectal carcinoma.