OGT and colorectal carcinoma: As shown in Figure 4D, knockdown of FASN leads to a significant decrease in proliferation of HCT116 cells, and overexpression of GFPT1, but not OGT, restores proliferation of FASNsh HCT116 cells, suggesting that GFPT1 plays a major role in promoting proliferation of CRC cells downstream of FASN.