In clinical practice, an association between increased FGF23 levels and left ventricular hypertrophy (LVH) has been observed independently of renal involvement [71], both in patients with normal FGF23 levels and no CKD [72], and in those with increased FGF23 levels in the context of CKD [73]. The gene discussed is FGF23; the disease is left ventricular hypertrophy.