VRK1 was independently depleted with two different siRNAs (siVRK1-02 and siVRK1-03) in A549 lung adenocarcinoma (Figure 1) cells, followed by serum deprivation (0.5% FBS) for 48 h and treated with 200 μM H2O2 for 15 and 30 min to accumulate cells in G0 and avoid the mitogenic signals that activate VRK1 and induce cell cycle progression [58,59]. Here, VRK1 is linked to lung adenocarcinoma.