Although endoplasmic reticulum (ER)-associated degradation and the unfolded protein response are two key quality-control machineries in the cell, it is suggested that BCL-2 is connected to ERAD protein synthesis regulation, but upregulation of BAX gene may be associated with UPR activation in response to the accumulation of misfolded proteins during chronic inflammation in RA patients [5]. The gene discussed is BAX; the disease is rheumatoid arthritis.