Under iron deficiency conditions, binding of IRPs to IREs inhibits the translation of mRNAs with 5′-IRE stem loops such as ferritins and ferroportin (FPN), whereas it stabilizes the mRNAs that contain 3′-IREs such as the transferrin receptor (TfR1) and divalent metal transporter (DMT1). Here, TFRC is linked to Iron deficiency anemia.