MIF suppression of NR3C2 occurs via upregulation of miR-301b, which binds the 3′ untranslated region of NR3C2 and inhibits its activity [44,175,176] MIF is also present in pancreatic cancer-derived exosomes, which drive the expression, recruitment, and differentiation of myeloid-derived suppressor cells in the TME [177,178,179]. Here, MIF is linked to familial pancreatic carcinoma.