CD8A and neoplasm: IFN-γ signaling is particularly important in tumor infiltration and functions by polarizing tumor-associated macrophages (TAMs) from an M2-immunosuppressive type to an M1-pro-inflammatory type; however, it also reduces the presence of CD4 and CD8 T cells in the TME via MIF/CD74 signaling [7,61,104,105,106,107].