AKT1 and cancer: MIF and DDT promote cell regeneration and proliferation in cancer by activating the ERK1/2, PI3K-Akt, NFκB, and AMPK pathways, which subsequently activate downstream NF-κB/P-TEFb complexes and drive c-Myb transcription [3,55,56,57,58,59,60,61,62,63,64].