As is well-known, the low-density lipoprotein (LDL) cholesterol oxidation in the blood vessels is the basis of the atherosclerosis process, further responsible for the inflammatory response from the arterial vessel wall in humans; thus, studies on ischemic heart disease in rats with induced atherosclerosis through an atherogenic diet indicated that the red grape pomace has the ability to decrease the TNF-α and IL-10 levels, to increase the level of the anti-atherogenic high-density lipoprotein (HDL) cholesterol and also to reduce the size and number of atherosclerotic lesions in rats [167]. Here, TNF is linked to atherosclerosis.