Interestingly, Gromovsky et al.’s study showed that Fads1 knockdown exacerbates hypercholesterolemia and increases free cholesterol level in the livers of LDLR null mice, likely through LXR-dependent and independent mechanisms [18], highlighting a critical role of FADS1 in the regulation of cholesterol metabolism. Here, FADS1 is linked to familial hypercholesterolemia.