We selected the melanoma model developed by our group, where we demonstrated an aberrantly expressed metabotropic glutamate receptor 1 (Grm1, mouse; GRM1, human) in the etiology of metastatic melanoma in transgenic [TG3 and Tg(Grm1)EPv] mouse models and subsequently showed its significance in the progression of human malignancy [29]. The gene discussed is GRM1; the disease is metastatic melanoma.