MYCN and neuroblastoma: To characterize the effects of modulating the LIN28B/let-7 interaction on the NB cell phenotype, we analyzed four NB cell lines for LIN28B and MYCN expression levels and downregulated LIN28B expression in two of them, namely CHP134 and NB69, which express different levels of LIN28B and have different MYCN amplification status, being MYCN-amplified and MYCN-non-amplified, respectively [24] (Figure 1A).