Specifically, LIN28B selectively blocks the processing of let-7 miRNA precursor molecules into mature miRNAs, resulting in lower amounts of mature let-7 miRNAs [22,23], which in turn cannot exert their tumor suppressor activity by directly repressing several well-known oncogene targets, including RAS, MYC, HMGA2, and BLIMP1 [20,21]. This evidence concerns the gene LIN28B and neoplasm.