TH and neoplasm: Furthermore, EGCG-NP treatment in CHP134 cells, which have been reported to be prone to differentiation upon specific stimuli, such as 13-cis-retinoic acid treatment [33], led to a significant decrease in the mRNA levels of the tumor markers MYCN, SOX2, and SOX9 and a significant increase in the differentiation markers TUBB3, GAP43, and TH (Figure 5C).