Among the downregulated genes in pterygium, CXCL11, ADAR, XAF1, ZBP1, HERC5, CIITA, IL6, IL10, IL12RB2, IRF3, CGAS, SOD2, and CMA1 have been found to be directly or indirectly associated with JAK/STAT signaling pathways [67,68,69,70,71,72,73,74,75,76,77,78,79,80]. This evidence concerns the gene IL6 and pterygium.