Among the downregulated genes in pterygium, CXCL11, ADAR, XAF1, ZBP1, HERC5, CIITA, IL6, IL10, IL12RB2, IRF3, CGAS, SOD2, and CMA1 have been found to be directly or indirectly associated with JAK/STAT signaling pathways [67,68,69,70,71,72,73,74,75,76,77,78,79,80]. The gene discussed is HERC5; the disease is pterygium.