In this manuscript, we compare the alterations in the renal transcriptome of two mouse models of TSC cystogenesis that lead to the disappearance of A-IC cells and abrogated cyst formation (Tsc1/Foxi1I dKO) or significant reduction in A-IC cell numbers and delayed cystogenesis (Tsc1/Car2 dKO) to that of WT mice. Here, CA2 is linked to tuberous sclerosis.