These studies focus on the process of renal cystogenesis in a mouse model of TSC renal cystic disease; however, additional TSC disease models that are available, such as heterozygote Tsc2 KO (Tsc2+/−) and other cell-specific knockout models, need to be examined in order to confirm the role of Car2 in TSC renal cystogenesis. This evidence concerns the gene CA2 and tuberous sclerosis.