In Lucena cells, there was an increase in CCL2/MCP-1, IL-6, IL-8 and Serpin E1/PAI-1, and a decrease in CXCL12/SDF-1 in cells transwell cultured with MSC-H compared with those transwell cultured with MSC-AML. The gene discussed is SERPINE1; the disease is acute myeloid leukemia.