MMP3 and rheumatoid arthritis: A promising avenue for intervention is the use of CBD, which has been shown to elevate intracellular calcium levels, reduce cell viability, and decrease IL-6, IL-8, TNF-α, IL-17A, and matrix metalloproteinase-3 (MMP-3) production in rheumatoid arthritis synovial fibroblasts (RASFs) and other inflammatory diseases including psoriasis [8,9].