Importantly, although certain tumor types such as neuroendocrine and breast cancers, as well as sarcomas, were over-represented amongst tumors with high ADORA2A expression in our study, and colorectal and ovarian cancers were underrepresented amongst tumor types with high ADORA2A, transcript levels varied from tumor to tumor, both between and within histologies. Here, ADORA2A is linked to breast carcinoma.