However, unexpectedly, high ADORA2A RNA levels may be a general favorable prognostic factor for better survival outcomes in patients with advanced/metastatic cancers, consistent with prior data showing that ADORA2A function is more nuanced than initially assumed, and may have a tumor suppressor effect [19] in addition to its pro-tumorigenic effects. This evidence concerns the gene ADORA2A and metastatic malignant neoplasm.