The protective effect of Nrf2 in maintaining the barrier has been proved in various experimental models, including P. gingivalis infection, dextran sodium sulfate-induced colitis, intestinal ischemia-reperfusion, aspirin/NSAID-induced vascular damage, intestinal burn, severe sepsis, and traumatic brain injury-induced intestinal mucosa damage and epithelial barrier dysfunction [10]. The gene discussed is NFE2L2; the disease is Sepsis.