A meta-analysis of SSc-PH associated antibodies demonstrated that SSc-PAH patients had a high prevalence of anti-centromere antibodies, anti-U3 RNP antibodies, anti-Th/To antibodies, and antiphospholipid antibodies, while associations were not seen in Scl-70 or RNA polymerase III [40]. The gene discussed is RNPC3; the disease is systemic sclerosis.