Increased expression of Notch1, Notch3, Jagged1, and Herp2 was documented in mouse model of hypoxia-induced PAH and rat model of monocrotaline-induced PH, and soluble Jagged1 treatment can improve the survival of PH by attenuating Notch pathway [140]. This evidence concerns the gene NOTCH3 and pulmonary arterial hypertension.