Importantly, no upregulation of progenitor markers, such as neurogenin 3 (NEUROG3), POU class 5 homeobox 1 (POU5F1), and nanog homeobox (NANOG) was found in T2D β-cells, in contrast to what was previously reported in diabetes mouse models [3]. Here, NEUROG3 is linked to type 2 diabetes mellitus.