CXCL16 and pancreatitis: In addition, Sakuma et al. identified chemokine CXCL16 as an acute pancreatitis maker from patient serum samples, and demonstrated that the CXCL16 knockout mice had attenuated pancreatitis-induced acini necrosis due to the decreased expression of CCL9, which attracted neutrophil infiltration in the pancreas [59].