In addition, Sakuma et al. identified chemokine CXCL16 as an acute pancreatitis maker from patient serum samples, and demonstrated that the CXCL16 knockout mice had attenuated pancreatitis-induced acini necrosis due to the decreased expression of CCL9, which attracted neutrophil infiltration in the pancreas [59]. The gene discussed is CXCL16; the disease is acute pancreatitis.