NQO1 and cancer: The target genes of NRF2 were classified initially as xenobiotic detoxication enzymes and oxidant/redox scavenger enzymes such as NAD(P)H quinone dehydrogenase 1 (NQO1) [16]; however, now, a wide range of target genes affecting homeostasis and cell fate have been defined that include anti-inflammatory, metabolism, cancer onset/progression and cell-death with efferocytosis signaling and post-transcriptional regulators (miRNA) [17].