As anticipated from the histochemical analyses, plasma alanine transaminase (ALT) activity from RbpjF/F::AlbCre mice was remarkable higher than control genotype mice (AlbCre and Keap1F/F::AlbCre mice that did not suffer cholestasis) and elevated to a similar degree in Keap1F/F::RbpjF/F::AlbCre mice at 3 W. ALT returned to the levels of control mice by 4 W and 9 W of age in RbpjF/F::AlbCre mice. This evidence concerns the gene GPT and cholestasis.