SREBF2 and cholestasis: Altered NOTCH or NRF2 signaling might affect cholesterol synthesis; however, the accumulation of hepatic cholesterol was not associated with the activation of the biosynthesis pathway under the conditions of cholestasis at 3 W. In 4 W-old post-weaning RbpjF/F::AlbCre mice, hepatic transcript levels of cholesterogenesis genes were upregulated remarkably and accompanied by Srebp2 transcripts compared to mice of the Keap1F/F::RbpjF/F::AlbCre and Nrf2F/F::Keap1F/F::RbpjF/F::AlbCre genotypes.