NFE2L2 and cholestasis: Even though genetic excision was successfully detected (Supplemental Figure S6), there was still the possibility that the remaining NRF2 in the hepatocytes of Nrf2F/F::Keap1F/F::RbpjF/F::AlbCre mice could function in the livers of Keap1F/F::RbpjF/F::AlbCre mice at 3 W under cholestasis conditions.