An imbalance in a severe cecal ligation and puncture (CLP) model of mouse sepsis between mitochondrial fission and fusion with dynamin-related protein 1 (Drp1) activation and optic atrophy 1 (OPA1) downregulation was demonstrated in association with mitochondrial structural abnormalities, mitochondrial dysfunction, and reduced cardiac contractility [35]. The gene discussed is DNM1L; the disease is Sepsis.