BDNF and Brain atrophy: Mimicking brain-derived neurotrophic factor (BDNF) action using small molecules (7,8-dihydroxyflavone and 4′-dimethylamino-7,8-dihydroxyflavone) in N171-82Q for example reduced motor deficits and brain atrophy, at least partially by mitigating impaired neurogenesis [91].