BDNF and Huntington disease: Other neuropathological features of HD besides mHtt toxicity include reduced brain-derived neurotrophic factor (BDNF) levels [16]; neuroinflammation, mitochondrial dysfunction, and oxidative stress [17]; impaired cellular signaling [18]; cerebrovascular deficits [19,20], as well as impaired cerebrospinal fluid flow and compromised clearance of toxic material from the brain [21].