In other cases, such as liver fibrosis, it was necessary for the TSP-1 domain to be combined with the IGFBP and VWC domains to promote the interaction between CTGF and slit guidance ligand 2 (SLIT2) in cultured hematopoietic stem cell (HSC) and fibrotic murine livers. Here, CCN2 is linked to Hepatic fibrosis.